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POLARIS technology
Immune Regulation through the feed

POLARIS is a patented fermentation-derived postbiotic technology that modulates the immune response to preserve productive performance under the full range of challenges in modern swine production.

Patented Technology Fermentation-Derived GMP+ Certified
What is POLARIS

Not a probiotic. Not a vaccine. Something different.

POLARIS is a postbiotic technology platform, a defined, fermentation-derived bioactive matrix that interacts with the immune system through the gut, without relying on live microorganisms or disease-specific mechanisms.

Fermentation-Derived Postbiotic
Produced through controlled fermentation, POLARIS is a defined composition of bioactive metabolites. No live microorganisms, consistent, scalable, and stable across production batches.
Defined Composition
Feed Additive Format
Delivered via feed inclusion, POLARIS acts through the gut-associated lymphoid tissue, GALT, the largest immune organ in the body. Simple to integrate, no separate administration required.
In-Feed Delivery
Foundational Technology
POLARIS is the scientific core inside DRIPEM products. Its biological activity underpins every immune regulation claim. Designed to work across species, production systems and challenge conditions.
Patented Platform
Built on Proven Science

Decades of research.
One focused technology.

POLARIS was not built overnight. It is the product of more than five years of dedicated laboratory research and two decades of commercial development across species and production systems. The result is a technology with deep scientific roots and a track record of practical application, wherever immune dysregulation stands between animals and their productive potential.

0yrs
Commercial Development
Two decades of refinement across real production environments and challenge conditions
0yrs
Dedicated Lab Research
Intensive immunological and nutritional research to validate the mechanism of action
+species
Cross-Species Application
Validated across species wherever immune dysregulation drives performance loss
Technology

How POLARIS Works

Watch how POLARIS technology works, its mode of action, and its application in swine.

POLARIS Technology, Mode of Action and Swine Application

The Challenge

Every immune challenge costs performance

Weaning stress, heat, viral pressure and high stocking density all trigger the same cascade inside the animal. The immune system activates, and nutrients that should drive growth are redirected toward survival.

Immune Activation Triggers
What happens inside the animal
Viral StressPrimary Factor
Pathogens dysregulate immune response and exploit weaknesses
Weaning Stress
Abrupt transition dysregulates immune balance
Heat Stress
Thermal load elevates oxidative burden
High Stocking Density
Density amplifies immune stimulation events
Immune response dysregulates
Pro-inflammatory cytokines cascade in an uncontrolled response, increasing the biological cost of immunity
Feed intake drops
Cytokine signalling suppresses voluntary intake, reducing available nutrients for growth
Immune defences become suppressed
Prolonged dysregulation exhausts the immune system, weakening the animal's ability to respond and leaving it open to secondary infection
ADG, FCR and uniformity suffer
The cumulative effect shows up in mortality, daily gain and feed efficiency across the herd
The Downstream Problem

Farms are forced to treat the symptoms, not the cause

When immune dysregulation goes unaddressed, farms have historically reached for antibiotics and chemical interventions to manage the visible consequences. Mortality, respiratory disease, growth failure and herd inconsistency become recurring problems that are treated reactively, cycle after cycle. The underlying immune imbalance that drives these outcomes is rarely targeted directly.

Antibiotic Dependency
Reactive treatment of infections that thrive in immunocompromised animals
Repeated Treatment Cycles
Challenges recur because the immune environment is never restored to balance
Rising Cost of Production
Chemical interventions add cost without improving the underlying nutritional efficiency

There is a different approach, one that works at the root of the problem, modulating the immune response itself so that animals stay productive under stress without relying on chemical intervention.

Mode of Action

Regulated Immune Response,
even under viral stress.

POLARIS does not boost the immune system indiscriminately, it regulates it. From the first point of contact in the gut, POLARIS guides the immune response through three connected stages, turning a stressed, dysregulated reaction into a controlled and durable one.

01
Dual Receptor Engagement
Delivered through feed, the POLARIS matrix is recognised at the gut-associated lymphoid tissue, GALT, and engages two of the immune system's central innate receptors, TLR2 and TLR4, at the same time. Engaging both together is what produces a controlled response instead of an indiscriminate one.
  • Recognised at the GALT, the body's largest immune interface
  • Engages TLR2 and TLR4 simultaneously
  • A measured trigger, not an indiscriminate stimulant
02
Balanced Th1 Polarisation
Under stress the immune balance tips away from Th1 and toward Th2 and Th17, weakening antiviral defence. POLARIS restores that balance, polarising the response toward Th1 cell-mediated immunity, the pathway built for viral and intracellular pathogens, while keeping Th2 and Th17 in check.
  • Shifts the balance back toward antiviral Th1 immunity
  • Keeps Th2 and Th17 within their healthy range
  • Regulation, not boosting, a measured response
03
Durable Immune Memory
A regulated response is also a lasting one. POLARIS supports the build-up of immunological memory, so animals are primed to respond faster and stronger when challenged again, with protection that holds even after supplementation ends.
  • Builds trained, longer-lasting immune readiness
  • Supports the memory cell populations behind faster recall
  • Protection that persists beyond the feeding window

POLARIS is a nutritional resilience technology. By regulating the immune response from first recognition through to lasting memory, it sustains consistent, efficient productive performance under viral stress.

Scientific Foundation

Grounded in peer-reviewed science

The biological claims supporting POLARIS are underpinned by a body of peer-reviewed literature across immunology, oxidative physiology, protein metabolism and postbiotic science.

TLR2/TLR4 Mode of Action Cross-cutting Oxidative Stress Inflammatory Response Protein Metabolism Immune Memory
1
Zúquete et al. (2024) Combined TLR2/TLR4 activation equips dendritic cells to prime Th1 cells with gut tropism
iScience
2
Mansouri et al. (2025) TLR2 and TLR4 bridge physiological and pathological inflammation
Communications Biology
3
Mukherjee et al. (2016) TLR2 and TLR4-mediated host immune responses in major infectious diseases
Review
4
Beutler et al. (2001) Synergy between TLR2 and TLR4: a safety mechanism
Blood Cells Mol Dis
5
Liu et al. (2007) Signaling via TLR2 and TLR4 down-regulates T-cell effector functions
6
Hirata et al. (2008) Selective synergy in anti-inflammatory cytokine production via TLR4 + TLR2
Mol Immunol
7
Ellen Davis (2022) Immunometabolism and inflammation: a perspective on animal productivity
doi: 10.1093/af/vfac060
8
Hao Y, Xing M, Gu X (2021) Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs
doi: 10.3390/ani11051384
9
Hong, C., Huang, Y., Cao, S. et al. (2024) Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?
https://doi.org/10.1186/s40104-023-00964-8
10
Sánchez J., et al. (2022) The Connection Between Stress and Immune Status in Pigs: A First Salivary Analytical Panel for Disease Differentiation.
doi: 10.3389/fvets.2022.881435
11
Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-gamma: an overview of signals, mechanisms and functions
doi: 10.1189/jlb.0603252
12
Ayechu-Muruzabal V, Xiao L, et al. (2021) A Fermented Milk Matrix Containing Postbiotics Supports Th1- and Th17-Type Immunity In Vitro and Modulates the Influenza-Specific Vaccination Response In Vivo in Association with Altered Serum Galectin Ratios
doi: 10.3390/vaccines9030254
13
Mafe, A. N., et al. (2025) Postbiotics in Functional Foods: Microbial Derivatives Shaping Health, Immunity and Next-Generation Nutrition
https://doi.org/10.1002/fft2.70205
14
Huster KM., et al. (2004) Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
doi: 10.1073/pnas.0308054101
15
Xie D, Lu G, Mai G, Guo Q, Xu G. (2020) Tissue-resident memory T cells in diseases and therapeutic strategies
doi: 10.1002/mco2.70053
16
Báez-Magaña M, Alva-Murillo N, et al. (2025) Trained immunity in farm animals
doi: 10.1186/s13567-025-01594-w
17
Williams NH, Stahly TS, Zimmerman DR. (1997) Effect of chronic immune system activation on body nitrogen retention, partial efficiency of lysine utilization, and lysine needs of pigs
doi: 10.2527/1997.7592472x
18
McGilvray WD., et al. (2019) Immune system stimulation induced by porcine reproductive and respiratory syndrome virus alters plasma free amino acid flux and dietary nitrogen utilization in starter pigs
doi: 10.1093/jas/skz120
19
Humphrey B, Zhao J, Faris R. (2019) Review: Link between intestinal immunity and practical approaches to swine nutrition
doi: 10.1017/S1751731119001861

All references relate to peer-reviewed publications supporting the biological mechanisms of POLARIS technology. Internal trial data is documented separately in the DRIPEM Technical Dossier. For professional use only.